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Original Article
Effects of Endothelin A Receptor Antagonist to Cellular Proliferation and Apoptosis in Neonatal Rat Heart
Byung Min Choi, Kee Hwan Yoo, Young Sook Hong, Joo Won Lee, Soon Kyum Kim
Clin Exp Pediatr. 2003;46(7):668-678.   Published online July 15, 2003
Purpose : In order to investigate the role of endothelins in the cardiac development, the present study was designed to examine the effects of endothelin A receptor(ETAR) antagonist to the cellular proliferation and apoptosis in the neonatal rat heart. In addition, the expression of various regulatory genes in protein and mRNA levels by ETAR antagonist were examined. Methods : Neonatal...
Correlation between Chest Radiographic Findings and Respiratory Indices in Neonates with Respiratory Distress Syndrome
Yong-Hwan Chung, Youn-Jin Park, Chong-Woo Bae, Dong-Wook Sung
Clin Exp Pediatr. 2003;46(7):655-660.   Published online July 15, 2003
Purpose : The relationship between chest X-ray findings and respiratory indices, including the arterial-alveolar oxygen partial pressure ratio(a/APO2) and the ventilatory index(VI), indicators of the clinical respiratory status in neonates with respiratory distress syndrome(RDS), was examined in the present study. Methods : The records of 50 neonates, randomly chosen from 174 neonates treated with pulmonary surfactant(PS) in the Neonatal Intensive Care...
Immunocytochemical Study for Lactalbumin in Alveolar Macrophage of Human Milk Aspirated Mouse
Byoung Kil Han, Young Hun Chung
Clin Exp Pediatr. 2003;46(6):536-540.   Published online June 15, 2003
Purpose : Aspiration of foreign material into the lungs can cause acute or chronic pulmonary diseases. It is difficult to detect small amounts of aspiration due to the lack of safe, sensitive and specific diagnostic tests. Recently, in animal or human studies, it has been reported that immunochemistry for lactalbumin can be used to detect the minimal aspiration. So, the...
Echocardiographic Parameters of Pulmonary Atresia with Intact Ventricular Septum(PA/IVS)
Young Seok Lee, Yeo Hyang Kim, Myung Chul Hyum, Sang Bum Lee
Clin Exp Pediatr. 2003;46(5):484-489.   Published online May 15, 2003
Purpose : To understand morphologic and hemodynamic variations in patients with pulmonary atresia with intact ventricular septum(PA/IVS), and to decide the best treatment modalities, we measured right ventricular volume, inflow, and outflow valvular annulus size in these patients and compared them with those of normal newborns. Methods : Eight patients with PA/IVS diagnosed by echocardiography from January to December 2001...
Case Report
A Case of Coil Embolization in a 15-year-old Child with Pulmonary Sequestration
Hyo Bin Kim, Ja Hyung Kim, Jong Seung Lee, Soo-Jong Hong, Gyou Bo Sung
Clin Exp Pediatr. 2003;46(4):385-388.   Published online April 15, 2003
Pulmonary sequestration is a rare congenital mass of nonfunctional pulmonary tissue that lacks a normal-connection with the bronchial tree or the pulmonary arteries. It is clinically asymptomatic but when it is complicated with recurrent infection, it needs to be treated. Conventionally, surgical removal was recommended, but these days we are trying new and less invasive techniques, such as arterial embolization....
Original Article
Relationship between Body Fat Distribution and Metabolic Risk Factors in Adolescents
Dal Hyun Kim, Tae Jung Seong, Young Jin Hong, Byong Kwan Son, Soon Ki Kim
Clin Exp Pediatr. 2003;46(4):326-334.   Published online April 15, 2003
Purpose : The objectives of this study were to estimate the prevalence of obesity in adolescents; to study the association between obesity, blood pressure, and dyslipidemia; and to evaluate the superiority of waist circumference to waist/hip ratio(WHR) in central obesity. Methods : We selected 1382 adolescents(M : F=690 : 692) aged from 11 to 18 years(mean age; boys 15.0, girls 15.4)...
The Usefulness of Spot Urine Protein/Creatinine Ratio in Evaluating Proteinuria in Children and the Correlation between 24-hour Urinary Protein Amount and Spot Urine Protein/Creatinine Ratio
Seon Young Hong, Ji Young Kim, Woo Yeong Chung
Clin Exp Pediatr. 2003;46(2):173-177.   Published online February 15, 2003
Purpose : Recently, different results about factors affecting accurate quantitation of 24-hr urinary protein(24UP) amount using spot urine protein/creatinine ratio(PCR) have been reported. The current study was designed to evaluate correlation between 24UP amounts and PCR in children, and the effect of 24UP amounts, age, sex, and glomerular filtration rate(GFR) on this correlation. Methods : Among 94 patients who visited the...
Colon Perforation during Air Enema Reduction of Intussusception
Yong Kuk Kim, Hae Ra Im, Gwang Hoon Lee, Soo Jin Han, Yong Han Sun, Eell Ryoo, Kang Ho Cho, Hann Tchah, Hak Soo Lee
Clin Exp Pediatr. 2003;46(1):37-41.   Published online January 15, 2003
Purpose : Although air enema reduction has been known as a good method of diagnosis and treatment of intussusception, it could develop colon perforation. However, there have been few studies about this complication. So we analyzed the risk factors of colon perforation during air enema reduction in patients with intussusception. Methods : We reviewed the charts of 12 colon perforation patients...
Clinical Study of Childhood Accidents from a Hospital Over Ten Years with Regard to Foreign Body Aspiration
Cheol-Min Kim, Jun-Young Song, Ja Hyung Kim, Ki Soo Kim, Soo-Jong Hong
Clin Exp Pediatr. 2002;45(9):1134-1140.   Published online September 15, 2002
Purpose : Childhood accidents have been increasing recently. Accidents rank as the leading cause of childhood mortality and morbidity. We performed this study to evaluate the causes of childhood accidents. Methods : The authors analysed retrospectively the medical records of 6,410 cases of childhood accidental injuries who visited the emergency room of Asan Medical Center from January 1990 to December...
Case Report
A Case of Marshall-Smith Syndrome
Yeo Ok Moon, Woo Jong Shin, Youn Jeong Shin, Eun Sil Dong, Young Min Ahn
Clin Exp Pediatr. 2002;45(7):906-911.   Published online July 15, 2002
Marshall-Smith syndrome is characterized by a triad of facial dysmorphism, failure to thrive and accelerated osseous maturation. We report a one-month-old male infant with of this rare syndrome, with laryngeal anomalies who died at 6 months of age with pneumonia. This is the first case of Marshall-Smith syndrome in Korea.
A Case of Hypernatremic Dehydration in an Exclusively Breast-Fed Newborn Infant
Kyung Pil Park, Jin Kyung Kim, Heng Mi Kim
Clin Exp Pediatr. 2002;45(6):790-795.   Published online June 15, 2002
Sporadic reports of hypernatremic dehydration in breastfed newborn infants have appeared in medical literature for at least 3 decades. We report the first case of hypernatremic dehydration resulting from inadequate breast-feeding in Korea. A 14-day old baby, born to a mentally retarded mother, was transferred to our hospital with a body weight loss of 460 g since birth(17%) and a...
Original Article
A Change of Adrenal Androgen and Cortisol in Kawasaki Disease
Sun-Hee Lee, Jae-Hong Yu, Hong-Ryang Kil
Clin Exp Pediatr. 2002;45(5):654-658.   Published online May 15, 2002
Purpose : Endocrine and immune systems are connected and interdependent. Adrenal glands play an important role in this network and control the balance between serum levels of dehydroepiandrosterone sulfate(DHEAS) and cortisol. These steroids have an antagonistic effect on the T cell progression into Th1 and Th2 cells and on the induction of correlated interleukins. Therefore we evaluated the role of...
The Influence of the Preoperative Chronic Cyanosis on the Cardiac Troponin I in the Pediatric Cardiac Operation
Jinyoung Song, Sungkyu Lee, Jaeyoung Lee, Soojin Kim, Wooseup Shim
Clin Exp Pediatr. 2002;45(4):498-504.   Published online April 15, 2002
Purpose : The purpose of this study was to evaluate the perioperative myocardial damage in pediatric congenital heart disease with the cardiac specific protein of cardiac troponin I(cTpn-I). Methods : All 25 pediatric patients who were diagnosed with tetralogy of Fallot or double outlet right ventricle were classified as group A(acyanotic, SaO2 >90%), group B(mildly cyanotic, SaO2 >80-90%) and group C(moderately...
Case Report
A Case of Intestinal Perforation in Henoch-Sch nlein Purpura
Won Sik Kang, Chang Hwan Oh, Jae Young Kim, Young Taek Lee, Hye Jin Lee, Hee Jin Kim, Sung Won Kim
Clin Exp Pediatr. 2002;45(3):406-412.   Published online March 15, 2002
Henoch-Sch nlein purpura(HSP) is one of the most common vasculitic diseases of childhood, referred to as a leukocytoclastic vasculitis affecting small vessels. Although HSP related gastrointestinal symptoms are seen in up to 80% of patients during acute illness, these symptoms are usually transient. However, some patients with HSP have gastrointestinal major surgical complications such as intussusception, bowel infarction, necrosis, stricture,...
Original Article
Anemia and Serum Iron Status in Adolescent Female
Ju Rae Cho, Soon Ki Kim, Sang Kyu Park, Jeong Ok Hah
Clin Exp Pediatr. 2002;45(3):362-369.   Published online March 15, 2002
Purpose : Anemia is still the most common nutrient deficiency worldwide, especially in adolescence because of an insufficient supply of iron, an increased iron requirement due to accelerated physical growth and blood loss due to menstruation in girls. This study was designed to assess the anemia and serum iron status of middle school girls. Methods : Hematologic examinations, physical examinations and...
Assessment of Chromosomal Analyses of 1,180 Cases Suspected of Chromosomal Aberrations
Hyeon Kyoung Jeong, Eun Young Ahn, Sung Soo Rim, Eun Young Kim, Kyoung Sim Kim, Yong Wook Kim, Ki Bok Kim
Clin Exp Pediatr. 2002;45(3):311-319.   Published online March 15, 2002
Purpose : We have performed this study to obtain reference data for the distribution of chromosomal aberrations in Korea. Methods : We analyzed 1,180 chromosomal study cases from Kwang ju Christian Hospital during the past 25 years. 756 cases suspected of characteristic chromosomal aberration syndromes and 424 cases with hermaphroditism, mild sexual abnormalities, multiple anomalies, or mental & growth retardation...
Methemoglobinemia Associated with Diarrheal Disease before 2 Months of Ag
Ji Ah Jung, Jung Won Lee, Jeong Wan Seo
Clin Exp Pediatr. 2001;44(12):1387-1394.   Published online December 15, 2001
Purpose : Methemoglobinemia has been observed during a diarrheal illness among those who were not exposed to oxidizing agents in neonates and young infants. We performed the study to determine predisposing factors in this entity. Methods : The medical records of 24 patients were reviewed, who were admitted for diarrhea with methemoglobinemia to Ewha Womans University MokDong Hospital, from February 1994 to November 2000. The...
Case Report
A Case of Neonatal Urinary Ascites due to Bladder Perforation Treated with Urinary Drainage
Heng-Mi Kim, Su-Hee Kwak, Sung-Kwang Jung, Sang-Kwon Lee
Clin Exp Pediatr. 2001;44(8):948-953.   Published online August 15, 2001
Urinary ascites in newborns is a rare event that usually is associated with posterior urethral valves and other obstructing anomalies of the genitourinary tract. A case of neonatal urinary ascites without genitourinary tract abnormalities is reported. This premature male neonate was treated by artificial ventilation due to respiratory distress syndrome. The umbilical artery catheter was placed without difficulties and functioned...
A Case of Gastric Perforation Presenting with Secondary Localized Peritonitis Due to Bamboo in Stomach
Ji Hyoun Seo, Ji Young Hwang, Ki Su Kang, Chan-Hoo Park, Hyang-Ok Woo, Myoung Bum Choi, Hee-Shang Youn
Clin Exp Pediatr. 2001;44(7):837-840.   Published online July 15, 2001
Perforation after foreign body ingestion is rare. We report a 25-month-old girl who was diagnosed with a stomach perforation with secondary localized peritonitis caused by long, sharp bamboo. On admission, she had abdominal pain and fever. Simple abdominal erect & supine X-ray, abdominal ultrasonogram and computed tomography scan were normal. On the 6 th hospital day, gastrofiberoscopy was performed because...
Original Article
The Effectiveness of Propofol on Pediatric Cardiac Catheterization and Electrophysiologic Study
Woo Saeng Park, Myung Chul Hyun
Clin Exp Pediatr. 2001;44(7):773-777.   Published online July 15, 2001
Purpose : Our purpose was to evaluate the effectiveness of propofol on pediatric cardiac catheterization or radiofrequency catheter ablation. Methods : We measured the serial changes of arterial oxygen saturation, heart rate, systolic and diastolic blood pressure at 4 stages, a baseline(during normal sleep), stage 1(just after loading of propofol 2 mg/kg over 10 minutes), stage 2(10-15 minutes after propofol continuous...
Mean Corpuscular Hemoglobin Concentration as a Discriminating Tool between Hereditary Spherocytosis and Intravascular Hemolysis
Hae Young Park, Hwang Min Kim, Kyoung Ah Lee, Dong Il Won, Sei Myeng Park, Seok Won Park, Baek Keun Lim, Kil Young Kim
Clin Exp Pediatr. 2001;44(6):664-668.   Published online June 15, 2001
Purpose : The purposes of this study were to elucidate the diagnostic significance of mean corpuscular hemoglobin concentration(MCHC) for various kinds of hemolytic anemia, the mechanism of elevated MCHC in hereditary spherocytosis(HS). Methods : The subjects consisted of 39 cases of HS(group 1), 31 cases of intravascular hemolysis (IH) such as DIC, snake bite or hemolytic uremic syndrome(group 3), and sex...
Case Report
A Case of Renal Abscess in Healthy Child
Jin Yeong Jeong, Young Seo Park, Soo Youn Ham
Clin Exp Pediatr. 2000;43(7):1012-1015.   Published online July 15, 2000
Renal abscess is rare in children and presents varying features which often lead to delay or error in diagnosis. Fever, lumbar pain, abdominal pain and occasional flank mass are the usual presenting complaints but a high degree of suspicion is important for the early detection of renal abscess. Hematogenous seeding of the kidney or ascending infection from the urinary collecting system are two proposed...
Original Article
Kinetics of GABAA Receptors in An Animal Model of Irradiation-induced Neuronal Migration Disorders
Chan Jong Kim, Young Jong Woo, Min Cheol Lee
Clin Exp Pediatr. 2000;43(7):933-941.   Published online July 15, 2000
Purpose : A majority of patients with neuronal migration disorders(NMDs) in cortical structures suffer from medically intractable epilepsy. The role of NMDs on seizure susceptibility or epileptogenecity has not been well documented. In the present study, we established an experimental model of NMDs in Sprague-Dawley rats by exposing fetal rats to external irradiation in order to demonstrate epileptogenic effect of NMDs lesions. Methods : Pregnant...
Case Report
A Case of Diffuse Aspiration Bronchiolitis in a Dysphagic Infant
Ok Ja Choi, Bong Seong Kim, ung Hye Park, Soo-Jong Hong
Clin Exp Pediatr. 2000;43(6):842-845.   Published online June 15, 2000
Diffuse aspiration bronchiolitis is defined as a clinical entity characterized by a chronic inflammation of bronchioles caused by recurrent aspiration of foreign particles. Clinical symptoms are bronchorrhea, bronchospasm, and dyspnea, and chest radiographs show the presence of regional or disseminated small nodular shadows and hyperlucency. Chest CT should help in detecting diffuse nodular shadows of bronchiolitis. Pathologic findings of diffuse...
Original Article
Effects of Respiration on Right and Left Ventricular Diastolic Function in Normal Children
Hae-Soon Kim, Young Mi Hong
Clin Exp Pediatr. 1999;42(10):1412-1418.   Published online October 15, 1999
Purpose : To evaluate the effects of respiration on diastolic filling pattern in normal children by Doppler echocardiography. Materials and Methods : Doppler echocardiograms of the tricuspid and mitral valves were recorded with electrocardiogram and respirations in 46 normal children aged 3months to 14years(7.6¡¾3.5year). We measured the following variables: heart rate, the peak E and A velocities, the area under the...
Effects of Cisapride on Action Potential Duration and on ATP-Sensitive K Channel in Guinea Pig Ventricular Muscles
Chan Uhng Joo, Young Jae Kim, Sung Ki Mun, Soo Wan Chae
Clin Exp Pediatr. 1999;42(7):953-958.   Published online July 15, 1999
Purpose : Cisapride(PrepulsidⓇ) has been recently associated with long QT syndrome. It has been reported to cause Torsades de Pointes and induce early afterdepolarization in rabbit Purkinje fibers. We investigated the electrophysiological effects of cisapride on cardiac action potential duration and ATP-sensitive K channel in papillary muscles. Methods : Cardiac action potentials in guinea pig papillary muscle were recorded with microelectrodes...
Cell Proliferation and Apoptosis in Heart of Trisomy 16 in Mice
Eun Jung Bae, Yong Soo Yun, Jung Sun Kim, Jeong-Wook Seo
Clin Exp Pediatr. 1999;42(5):621-630.   Published online May 15, 1999
Purpose : Although abnormal developments of cushion and atrioventricular septum have been suggested, the exact mechanism for the development of atrioventricular septal defect is not well known. We aimed to identify the role of cell proliferation and apoptosis on cardiac morphogenesis in trisomy 16 mice(an animal model for Down's syndrome in human). Methods : We examined the difference in cardiac...
Clinical Study of Multiple Intestinal Ulcerations and Perforations Caused by Methicillin-Resistant Staphylococcus aureus in Infants
Seok Joo Han, Poong Man Jung, Jai-Eok Kim, Jeong Hong, Hoguen Kim, Inwha Seong, Eui Ho Hwang
Clin Exp Pediatr. 1999;42(1):77-87.   Published online January 15, 1999
Purpose : In recent years, the authors experienced a distinctive clinical entity of multiple intestinal ulcerations and perforations in infants. The purpose of this study was to describe the clinical characteristics of this entity, examine th possible pathogenesis and the effective treatment. Methods : Seven infants underwent abdominal exploration under suspicion of surgical abdomen and were noted to have multiple intestinal...
Random Urine Ca/Cr Ratio in Healthy Neonates
Hea Young Lee, So Young Park, Eun Sun Yoo, Eun Ae Park, Seung Joo Lee
Clin Exp Pediatr. 1998;41(3):378-382.   Published online March 15, 1998
Purpose : Recently, in high risk preterm infants, we experienced high incidence of hypercalciuria, nephrolithiasis & nephrocalcinosis. To screen hypercalciuria, we need the normal value of random urine Ca/Cr ratio in healthy neonates according to gestational age, postnatal age, milk and calcium intake. Methods : Random urine Ca/Cr ratio was checked in 260 healthy full-term infants at the 2-7th day, and...
Clinical Study and Diagnostic Value of the Lung Perfusion Scan in Foreign Body Aspiration
Gyo-Dang Koo, Young-Ho Rah, Chong-Woo Bae, Sa-Jun Chung, Yong-Mook Choi
Clin Exp Pediatr. 1998;41(1):74-80.   Published online January 15, 1998
Purpose : Early diagnosis of foreign body aspiration and removal of the inhaled material may save the patient from chronic illness and may prevent serious complications. At present the diagnostic problems of bronchial foreign bodies are being solved by using the lung scanning technique. Therefore, we investigated the clinical study and diagnositic value of the lung perfusion scan in foreign body aspiration. Methods : Eighteen...
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